Nuclear architecture and gene regulation

Nuclear Architecture and Gene Regulation in Mammalian Cells

tion of gene expression and other nuclear functions — namely the architecture of the nucleus as a whole. In particular, we describe evidence for a compartmentalized nuclear architecture in the mammalian cell nucleus based on chromosome territories (CTs) and an interchromatin compartment (IC) that contains macromolecular complexes that are required for replication, transcription, splicing and re...

Nuclear Architecture and Epigenetics of Lineage Choice

Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...

β-Globin Gene Regulation and Nuclear Organisation

nuclear architecture and epigenetics of lineage choice

differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. a number of studies have reported the effects of biochemical modifications of chromatin (dna and chromatin proteins) on the regulation of transcription. although, these studies are able to explain how transcription of a given gene is regulated (toward activation...

Gene expression and nuclear architecture during development and differentiation

Development requires a precise program of gene expression to be carried out. Much work has focussed on the regulatory networks that control gene expression, for example in response to external cues. However, it is important to recognize that these regulatory events take place within the physical context of the nucleus, and that the physical position of a gene within the nuclear volume can have ...